Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/307620761?client_source=feed&format=rss
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Thursday, May 23, 2013
Thursday, May 16, 2013
Four genes identified that influence levels of 'bad' cholesterol
May 15, 2013 ? Scientists at the Texas Biomedical Research Institute have identified four genes in baboons that influence levels of "bad" cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.
"Our findings are important because they provide new targets for the development of novel drugs to reduce heart disease risk in humans," said Laura Cox, Ph.D., a Texas Biomed geneticist. "Since these genes have previously been associated with cancer, our findings suggest that genetic causes of heart disease may overlap with causes of some types of cancer."
The new study, funded by the National Institutes of Health (NIH), is published online and will appear in the July print issue of the Journal of Lipid Research.
Texas Biomed scientists screened their baboon colony of 1,500 animals to find three half-siblings with low levels of low density lipoprotein (LDL), or "bad,"' cholesterol, and three half-siblings with high levels of LDL. In the study, these animals were fed a high-cholesterol, high-fat diet for seven weeks. Scientists then used gene array technology and high throughput sequencers to home in on the genes expressed in the two groups and differentiate those in the low LDL groups from those in the high LDL group. They discovered that four genes (named TENC1, ERBB3, ACVR1B, and DGKA) influence LDL levels.
Interestingly, these four genes are part of a signaling pathway important for cell survival and disruption of this pathway promotes some types of cancer.
It is well-known that a high level of LDL is a major risk factor for heart disease. Despite concerted efforts for the past 25 years to manage cholesterol levels through changes in lifestyle and treatment with medications, heart disease remains the leading cause of death and mortality in the United States and around the world. It will account for one out of four U.S. deaths in 2013, according to the American Heart Association.
Heart disease is a complex disorder thought to be a result of interactions between genetic and environmental factors, which occur primarily through diet. To understand why humans have different levels of LDL and thus variation in risk for heart disease, the genetic factors causing these differences need to be understood.
However, these studies are difficult to do in humans because it's practically impossible to control what people eat. Instead, Texas Biomed scientists are using baboons, which are similar to humans in their physiology and genetics, to identify genes that influence heart disease risk.
The new research also suggests that knowing many of the genes responsible for heart disease may be necessary to devise effective treatments. For example, several genes may need to be targeted at once to control risk.
The next step in this research is to find the mechanism by which these genes influence LDL cholesterol. "That starts to give us the specific targets for new therapies." Cox said. If all goes well, this information may be available within two years.
Other Texas Biomed scientists on the study included Genesio Karere, Ph.D.; Jeremy Glenn, B.S.; Shifra Birnbaum, B.S.; David Rainwater, Ph.D.; Michael Mahaney, Ph.D.; and John L. VandeBerg, Ph.D.
This research was supported by NIH grants P01 HL028972-27, P01 HL028972 Supplement, and P51 OD011133. It was conducted in part in facilities constructed with support grants C06 RR013556 and C06 RR015456.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/ds2Kji5Ual4/130515131444.htm
Wednesday, May 15, 2013
Netflix Video Traffic Jumps 35 Percent
Netflix continues to be the biggest hog of Internet bandwidth in North America, with its video traffic jumping more than 35% in March from a year earlier, according to a new study.
The video-subscription company accounted for roughly one-third (32.3%) of peak-period downstream traffic on fixed-line broadband networks in North America, about the same as last spring, an analysis by network equipment vendor Sandvine found.
YouTube?s video usage has surged at an even faster pace in the past year, now accounting for 17.1% of downstream Internet traffic in North America, up from 13.8% a year ago, according to Sandvine?s study.
At the same time, overall average monthly consumption by broadband users in the region?rose 39% year over year, to an aggregate mean of 44.7 gigabytes. That means Netflix?s overall data load increased in line with that because its share remained approximately the same and YouTube?s bandwidth growth would have exceeded that rate. (Sandvine doesn?t report data usage estimates by application in absolute terms.)
Netflix said it streamed more than 4 billion hours of video globally in the first quarter of 2013, compared with 1 billion per month last June. The company has packed on customers, adding about 2 million U.S. streaming subs to stand at 29.17 million domestically ??making it bigger than HBO?in that regard.
Netflix could grow to be two to three times the size of HBO, to 60 million to 90 million subscribers worldwide, topper Reed Hastings said on the company?s earnings call with analysts last month. ?We?ll really only know that with any confidence when we get there,? he said.
To manage costs as Internet video traffic continues to soar, Netflix has embarked on a program dubbed Open Connect aimed at broadband service providers. By directly connecting with ISPs, Netflix saves money on content-delivery costs.
As an incentive to get service providers on board, Netflix allows Open Connect partners to provide higher-quality Super HD and 3D titles to their mutual customers. Optionally, ISPs can deploy Netflix-supplied caching servers in their data centers for additional performance gains.
Of the top 15 broadband providers in the U.S., Netflix has signed up Cox Communications, Cablevision Systems and Suddenlink Communications for Open Connect. Netflix has emphasized that it doesn?t ask for any payment from ISPs to hook into its private content delivery network.
Meanwhile, Netflix and YouTube are pushing the limits on mobile networks, too, although average mobile Internet data usage is less than 1% that of fixed-line networks in North America, according to Sandvine. YouTube represents 27.3% of downstream mobile Internet data, while Netflix had a share of 4% (up from 2.2% a year earlier).
The data in Sandvine?s report was collected from a sampling from Sandvine?s customer base of 200 service providers worldwide.
Source: http://www.rottentomatoes.com/m/1927467/news/1927467/
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Sunday, May 12, 2013
Mother, daughter fight breast cancer (video) - Victoria Advocate
Breast Cancer Statistics
About 1 in 8 women in the United States will develop an invasive breast cancer over the course of her lifetime.
??As of 2011, more than 2.6 million breast cancer survivors lived in the U.S.
??In 2009, 211,731 women in ...
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Breast Cancer Statistics
About 1 in 8 women in the United States will develop an invasive breast cancer over the course of her lifetime.
??As of 2011, more than 2.6 million breast cancer survivors lived in the U.S.
??In 2009, 211,731 women in the U.S. were diagnosed with breast cancer.
??This year, the American Cancer Society estimates there will be 232,340 new cases of invasive breast cancer diagnoses. About 64,640 cases will be the earliest form of breast cancer.
source: american cancer society
To learn more
Contact the American Cancer Society, 4401 Lilac Lane in Victoria, or call 361-578-2849.
"Wah, wah, wah, wah, wah," is what Linda Amaro heard in October - the voice of what sounded like Charlie Brown's teacher saying indecipherable nothings.
Amaro felt the world stop, and she felt the air leave the room.
"You have breast cancer," the voice of her oncologist became clear now, as did the reality of her diagnosis.
The 48-year-old crumbled. She felt defeated and broke the news to her tight-knit family.
Her only daughter, Dionne Vela, 33, worried not only for her mom but also for herself. She decided the lump in her breast could no longer be ignored.
One week later, Vela took Mom's advice and went to get checked.
Within hours, the doctor came into the room, and the same muffled voice began, unveiling a harsh coincidence.
"You have breast cancer."
The diagnosis
The tail end of 2012 was a hard time for the mother-daughter duo from Victoria.
Today, the two lean on one another even more because of their bond through cancer. While this Mother's Day will be strikingly different from those in the past, the two feel even closer.
"I wasn't important anymore," Amaro said through tears about her daughter's diagnosis. "Everything changed. As a mother, she was important."
Amaro, who works at Wal-Mart Supercenter, first felt a dull pain in her left breast in September. The soreness lingered until her husband finally convinced her to see her doctor.
She had no lump, so the process took days, until Oct. 23, when she received the call that she had breast cancer.
Vela stayed strong for her family, but in secret, she would find time to let the tears flow.
As her mother began coping with her diagnosis, that's when Vela found out about her breast cancer.
The diagnosis took one day.
Vela's lump was large and had metastasized. A biopsy confirmed her worst fear.
"I cried for days," Vela said, dabbing a tissue under her eyes, careful not to smudge the makeup that still makes her feel beautiful. "Your life flashes before your eyes. I know they say that a lot, and it really does happen."
Though diagnosed with the same cancer, there is something very different about the two that makes it hard for any mother to understand.
"Mine is an early stage," Amaro said. "But Dionne's is not."
An unbreakable bond
Vela, a stay-at-home mom, doesn't like thinking of her cancer in stages, but the truth is she is at stage 4.
"The stage is what scares you," she said.
Immediately after being diagnosed, Vela had eight aggressive chemotherapy treatments to downsize the tumor, which was the size of a grapefruit.
In about one week, Vela will begin radiation treatments, while her mother just started chemotherapy.
They both coach one another about what they've experienced.
Vela shares the frightening reality of waking up to find clumps of hair on her pillow, and her mother shares what a 13-hour-long double mastectomy with reconstruction feels like.
Her mother is not the only one in the loop. Vela has made her cancer a family affair. When she decided to shave off her hair, she made a party of it.
She laughed, and she cried.
Both have not let their cancer stop them from living life. Every morning, Vela wakes up, puts on her jet-black wig, applies her makeup and pulls some of the best fashion in her closet off the hanger.
"I never wanted them to see me sick," Vela said of her husband and three children.
She refuses to let her cancer get the best of her or her mom.
The two continue going to softball and baseball games for Vela's children. They make it a point to laugh at the world - and even themselves sometimes - because that's how their family pushes through, they said.
"I say it's been a good adventure," Vela said.
"We're a very close family," Mom chimes in. "We're going to get through it together."
Source: http://www.victoriaadvocate.com/news/2013/may/11/jo_mothersday_051213_209195/
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Wednesday, May 8, 2013
Bob Ford: Hiring an assistant not a bad move for 76ers
Does it matters who coaches Sixers?
There are two seasons under way in the NBA. There is the playoff season and the coaching search season. The majority of teams in the league were involved in either one or the other this year, which is nothing new in an impatient win-or-change league.
Brooklyn hit the exacta by taking part in the postseason and then jumping immediately into a coach search by firing interim P.J. Carlesimo, who got them into the playoffs after Avery Johnson was let go. Carlesimo was asked what might have saved his job and he thought about it and said, "Maybe winning a championship."
Or maybe not. Atlanta is also expected to perform the playoff and coach- search double. Coach Larry Drew had the Hawks over .500 and in the postseason each of his three years, but the last two ended with first-round elimination, so he's probably out. I mean, it couldn't be because of the players he has, right?
At the moment, only four head coaches in the league have been at the same job longer than five full seasons, and, once all the current openings are filled, there will be close to 20 coaches hired since 2011. That's some serious turnover, and the 76ers once again find themselves among those in the spin cycle this offseason.
If the candidates who have emerged as possible replacements for Doug Collins seem a little underwhelming, that's probably because the available coaches view the Sixers' job the same way. Among the current openings, only Charlotte's represents a clearly worse situation than taking over the jumbled mess of a reclamation process in Philadelphia.
The reality is that it's a lot easier to win in the NBA with a good roster and an average coach than the other way around. So, does it really matter which of the available names is the one they select? It isn't as if hiring Jeff Hornacek, one of the rumored candidates, will burn up the phone lines in the ticket sales office.
The Detroit Pistons have taken the unusual step of contracting with Phil Jackson to assist general manager Joe Dumars with their coaching search. It is particularly unusual because Jackson is himself a candidate for the Nets job, at least according to the Nets. Jackson hasn't said much about it, waiting to consult his mah-jongg tiles or gray wolf droppings or whatever he's into these days.
The Nets, because they must operate in a market that requires at least artificial excitement - and contains another NBA team - have the flashiest of rumors at the moment. Along with Jackson, the Nets have been mentioned as considering a run at former Jazz coach Jerry Sloan and former everyone (including Nets) coach Larry Brown, although that probably means Larry is the only one mentioning it.
On the long list of candidates being considered by various organizations are Nate McMillan, Houston assistant Kelvin Sampson, Knicks assistant Darrell Walker, Indiana assistant Brian Shaw, Boston assistant Ryan McDonough, Milwaukee assistant San Antonio assistant Mike Budenholzer, Golden State assistant Mike Malone, Utah assistant Hornacek, interim Phoenix coach Lindsey Hunter, and, if he loses the Atlanta gig, Drew. Jeff Van Gundy and Stan Van Gundy are out there, too, as are Carlesimo and a few more guys, none of whom would either surprise or excite you as possibilities.
The Sixers seem likely to hire someone's assistant coach, which isn't necessarily a bad move. It would be a realistic and cost-effective way to approach the rebuilding that must take place, and the last nine months have put ownership on a first-name basis with reality.
If hedge fund billionaire Josh Harris is completely clear-eyed about the situation, he will also recognize the need to revamp his front office, which is losing Rod Thorn to retirement and, regardless of his consultant's title, is losing the everyday input of Collins, too.
To reach that conclusion, Harris will have to fight the impulse to think that either he or any member of his ownership group knows anything at all about the NBA, and he will have to be willing to spend a lot of his money to hire a player personnel executive who will slowly salvage the team. Unfortunately, given where they are, the emphasis will be on "slowly.
In all likelihood, the process will be so slow that the coach hired to begin the journey will not be around to see its completion. So, is there a real difference if the Sixers get Brian Shaw or Kelvin Sampson or Jeff Hornacek this time around? Probably not.
The coaching wheel has to keep turning, after all, and every head coach knows that if he isn't involved in the real NBA postseason, pretty soon he'll be involved in the other one.
Source: http://www.miamiherald.com/2013/05/07/3385803/bob-ford-hiring-an-assistant-not.html
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Monday, May 6, 2013
'Red Flags': Army takes note as vet rapper Soldier Hard's lyrics tackle suicide
NBC News
Jeff Barillaro, aka Soldier Hard, is an Iraq War veteran who has put his hip-hop talents to work. Barillaro sings gritty songs he hopes will raise awareness of PTSD and suicide.
By Bill Briggs, NBC News contributor
A hip-hop song beseeching battle buddies to be on watch for suicidal signals among their peers is being used ? informally for now ? within the Army as a prevention tool to help the branch stem an ongoing suicide crisis.
?Red Flags,? penned and recorded by former Army tank gunner Jeff Barillaro, was created as an urgent call for current troops as well as Iraq and Afghanistan veterans not to ignore or miss the sometimes-subtle yet often-obvious behavioral changes known to precede many suicides, Barillaro said.
?We?ve seen the red flags but we were blind to them,? said Barillaro, an Iraq War veteran who performs under the stage name Soldier Hard. Many of his songs and videos?draw on his own raw experiences with a diagnosis of severe Post Traumatic Stress Disorder.
Through the end of March, the Army reported 81 apparent suicides this year among active-duty, Army Reserve and National Guard troops ? one death every 26.7 hours. (Some cases remain under investigation). The fatal pace has increased slightly. During 2012, the Army reported 324 suicides within those groups ? one death every 27 hours, according to the Pentagon. The latest estimate from the Department of Veterans Affairs showed that 22 veterans commit suicide daily.
The Army ? the branch most significantly impacted by suicides ? has implemented an array of anti-suicide initiatives, but an Army Reserve adviser in Connecticut sees such a potent message in Barillaro?s lyrics, he believes the song can save lives.
?I want to share his music with anyone willing ,to listen. I think anyone can relate to 'Red Flags,' "?said Army 1st?Sgt. Steve Kreider, who is based at an?Army Reserve Center in Middletown, Conn. ?It strikes a chord that this is something we really need to keep an eye open for.?There are warning signs we have to recognize not only in other people but in ourselves ? I'm being reclusive or I'm drinking too much ? these are all signs that something is going on in your life that could be detrimental down the road."?
'Maybe we can stop it'
Kreider has shared ?Red Flags? with some of his soldiers in Connecticut ? and "for everyone of them, it's had a positive impact," he said. Meanwhile, another Army veteran recently played the song for soldiers at Fort Knox, Ky., Kreider said.?
Moreover, Kreider has now shared the video "with a lot of different higher-ranking people. I'm sure that they're looking at it closely to see if this is something that would fit the mold of what the military can utilize as a tool," he said.?
"And if not, word of mouth is a powerful took itself," he added. "It's close to going viral."?
Since the song?s video was released April 17 on YouTube, it has received nearly 17,000 views. The lyrics are rooted in two actual suicides that stuck hard with Barillaro as he researched the topic by clicking through a blur of military obituaries.
The first verse details a well-decorated Iraq War veteran who, once he shed his uniform and medals, lost his pride yet gained anger while grappling with PSTD, a traumatic brain injury, alcoholism and isolation before clutching a gun and scrawling a farewell note: ?I?m better off dead.? In verse two, an active-duty soldier is devastated by survivor guilt after the combat loss of a close friend. He ultimately hanged himself in his bedroom. (Two soldiers pictured in the video are living service members who allowed their images to be used.)
Iraq War veteran and hip-hop artist Jeff "Soldier Hard" Barillaro discovered that sharing his experience with PTSD in music helped him and other veterans deal with the effects of the condition. Barillaro talks to MSNBC's Alex Witt.
?He was a hard charger but now he?s just ate up,? Soldier Hard sings of the second man.
??Ate up? ? that?s a military term for being all messed up, for not being a good soldier anymore. This guy used to be good but after he came back, he just shut down,? Barillaro said. ?That?s a red flag. But we didn?t see that.
?Real topics. People can relate to these. I decided to turn their stories into a song,? he added. ?A lot of these guys, they?re showing signs before they actually do it. I decided I had to do something. Maybe we can stop it.?
Related:?
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Thursday, May 2, 2013
300 gallons of urine found in man?s home
LONDON, April 30 (Reuters) - For Rafael Nadal to bridge a 7,000-point gap with Novak Djokovic in the ATP rankings looks like a tall order, even for a player of his qualities, yet he could still threaten the Serb's hopes of ending 2013 as world No.1. With the French Open looming large on the horizon, Nadal is back in the claycourt groove as he continues his comeback from a knee injury that sidelined him for seven months. ...
Source: http://news.yahoo.com/blogs/sideshow/300-gallons-urine-found-inside-man-home-224127138.html
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