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Saturday, June 23, 2012

Best Home Improvements for Added Value | Improvements

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The best and most valuable home improvement idea will reward your investments of money and time with higher home value now and at the time you sell your home. In each of the past 15 years, over one million homeowners spent more than $ 10,000 on a kitchen, bath or other major remodeling project, according to Harvard University?s Joint Center for Housing Studies. And experts say such home improvements are generally a good investment.

But tackling a home improvement idea does not always mean an increase in the value of your home. While some projects will increase a home?s value, others may have the same payback as a losing lottery ticket. Before you open your checkbook, there are a few things you should consider to make sure the end result produces a return on your investment?in both time and money.

Value check: Before deciding how much to spend on a major improvement, get an estimate of the current value of your home. With such websites as AOL Real Estate, you can get started by entering your street address to get a current estimate of what your house might sell for in today?s market, as well as the prices that similar homes have recently sold for in your neighborhood. By comparing these prices with renovation estimates, you?ll avoid over-improving your home in relation to the neighborhood, a common and costly mistake. The best home improvement idea adds value while keeping your home price competitive for the neighborhood.

Motive check: Basically, there are two reasons to make major home improvements: pleasure or necessity. If you?re not planning to move for 10 years or more, you?ll have more time to enjoy your improvements and might not be as concerned about getting a return on the investment. However, if you?re improving your home to ultimately add to its resale value, you?ll need to prioritize and focus on the improvements that will pay off at sale time.

Reality check: Before calling in contractors, get a realistic estimate of what your project might cost by using one of the many available online cost estimators. Most provide an approximate cost of the most common home improvement projects along with data localized to your zip code to adjust for geographic cost differences.

Profit check: According to the National Association of the Remodeling Industry, the top five remodeling projects are kitchens, baths, other interior rooms, additions and window replacement. And Remodeling Online reports that even though the average minor kitchen remodel will cost about $ 15,000, you?ll see a return on that investment of 88 percent. Plus, fixing up that tired bathroom can deliver an 81 percent return if the house is sold within one year from the time the work is completed.

Considering all of these elements will help you to choose the best home improvements for your house, allowing you to create and maintain reasonable budgets for the projects you choose and enjoy a great return at sale time.

About the Author

The Money Pit is a publisher of home improvement content and the producers of the largest home improvement radio program in America. For more information about Money Pit and home improvement idea please go to www.moneypit.com.

Use and distribution of this article is subject to our Publisher Guidelines
whereby the original author?s information and copyright must be included.

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Tesla Model S first drive: the sports sedan goes electric

It's no secret that we have a few automobile enthusiasts in our midst here at Engadget, and we're pretty sure there are some in the audience as well -- you know who you are. Still, you don't have to be a car nut to appreciate all the innovation and technology that's gone into Tesla's sophomore vehicle -- the Model S electric sedan. So strap yourselves in and hold on to your kneecaps: you're about to ride along with us as we drive the Model S for the very first time. Excited? We are too -- hit the break for our impressions and stay tuned for our video.

Gallery: Tesla Model S drive

Continue reading Tesla Model S first drive: the sports sedan goes electric

Tesla Model S first drive: the sports sedan goes electric originally appeared on Engadget on Fri, 22 Jun 2012 21:20:00 EDT. Please see our terms for use of feeds.

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Friday, June 22, 2012

KCRW launches app on Spotify

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Enzyme offers new therapeutic target for cancer drugs

Public release date: 21-Jun-2012
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Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs.

Signal transduction in the cell involves kinases and phosphatases, enzymes that transfer or remove phosphates in protein molecules in a cascade or pathway. SRPK kinases, first described by Xiang-Dong Fu, PhD, professor of cellular and molecular medicine at UC San Diego in 1994, are involved in controlling the activities of splicing regulators in mammalian cells.

Prior studies have implicated SRPK1 in cancer and other human diseases. For example, it has been shown that SRPK1 plays a critical role in regulating the function of Vascular Endothelial Growth Factor or VEGF, which stimulates blood vessel growth in cancer. SRPK1 has been found to be dysregulated in a number of cancers, from kidney and breast to lung and pancreatic.

Conversely, studies suggest the absence of SRPK1 may be problematic as well, at least in terms of controlling some specific cancer phenotypes. Reduced SRPK1, for example, has been linked to drug resistance, a major problem in chemotherapy of cancer.

In their new paper, Fu and colleagues place SRPK1 in a major signal transduction pathway in the cell. "The kinase sits right in the middle of the PI3K-Akt pathway to specifically relay the growth signal to regulate alternative splicing in the nucleus," said Fu. "It's a new signaling branch that has previously escaped detection."

As such, the SRPK offers a new target for disease intervention and treatment, researchers say. "It's a good target because of its central role and because it can be manipulated with compounds that suppress its activity, which appears quite effective in suppressing blood vessel formation in cancer," Fu said.

###
Co-authors of the paper are Zhihong Zhou, Jinsong Qiu, Yu Zhou and Hairi Li, Department of Cellular and Molecular Medicine, UC San Diego; Liu Wen, Qidong Hu and Michael G. Rosenfeld, Howard Hughes Medical Institute, Department of Medicine; Ryan M. Plocinik and Joseph A. Adams, Department of Pharmacology, UC San Diego; and Gourisanker Ghosh, Department of Chemistry and Biochemistry, UC San Diego.

Funding came, in part, from National Institutes of Health grants GM52872, HG004659 and GM67969, the Ruth L. Kirchstein National Research Service Award (GM090484) and the Howard Hughes Medical Institute.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Enzyme offers new therapeutic target for cancer drugs Public release date: 21-Jun-2012
[ | E-mail | Share ]
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs.

Signal transduction in the cell involves kinases and phosphatases, enzymes that transfer or remove phosphates in protein molecules in a cascade or pathway. SRPK kinases, first described by Xiang-Dong Fu, PhD, professor of cellular and molecular medicine at UC San Diego in 1994, are involved in controlling the activities of splicing regulators in mammalian cells.

Prior studies have implicated SRPK1 in cancer and other human diseases. For example, it has been shown that SRPK1 plays a critical role in regulating the function of Vascular Endothelial Growth Factor or VEGF, which stimulates blood vessel growth in cancer. SRPK1 has been found to be dysregulated in a number of cancers, from kidney and breast to lung and pancreatic.

Conversely, studies suggest the absence of SRPK1 may be problematic as well, at least in terms of controlling some specific cancer phenotypes. Reduced SRPK1, for example, has been linked to drug resistance, a major problem in chemotherapy of cancer.

In their new paper, Fu and colleagues place SRPK1 in a major signal transduction pathway in the cell. "The kinase sits right in the middle of the PI3K-Akt pathway to specifically relay the growth signal to regulate alternative splicing in the nucleus," said Fu. "It's a new signaling branch that has previously escaped detection."

As such, the SRPK offers a new target for disease intervention and treatment, researchers say. "It's a good target because of its central role and because it can be manipulated with compounds that suppress its activity, which appears quite effective in suppressing blood vessel formation in cancer," Fu said.

###
Co-authors of the paper are Zhihong Zhou, Jinsong Qiu, Yu Zhou and Hairi Li, Department of Cellular and Molecular Medicine, UC San Diego; Liu Wen, Qidong Hu and Michael G. Rosenfeld, Howard Hughes Medical Institute, Department of Medicine; Ryan M. Plocinik and Joseph A. Adams, Department of Pharmacology, UC San Diego; and Gourisanker Ghosh, Department of Chemistry and Biochemistry, UC San Diego.

Funding came, in part, from National Institutes of Health grants GM52872, HG004659 and GM67969, the Ruth L. Kirchstein National Research Service Award (GM090484) and the Howard Hughes Medical Institute.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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The Volt Buckle Charges Your Phone, Holds Up Your Pants

Talk about convergence, eh? The Volt Buckle is described on its indiegogo fundraising page as "The world's first and only wearable mobile device wall charger." And as someone who has traveled around the Internet a time or two, I can attest to that claim. Never in all of my Internet days have I seen such a device. I want it.

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Thursday, June 21, 2012

University behavioral health - HEALTH, BEAUTY & FITNESS

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Alien world looms large in its neighbor's sky

Few nighttime sights offer more drama than the full Moon rising over the horizon. Now imagine that instead of the Moon, a gas giant planet spanning three times more sky loomed over the molten landscape of a lava world. This alien vista exists in the newly discovered two-planet system of Kepler-36.

"These two worlds are having close encounters," said Josh Carter, a Hubble Fellow at the Harvard-Smithsonian Center for Astrophysics (CfA).

"They are the closest to each other of any planetary system we've found," added co-author Eric Agol of the University of Washington.

Carter, Agol and their colleagues report their discovery in the June 21st Science Express.

They spotted the planets in data from NASA's Kepler satellite, which can detect a planet when it passes in front of, and briefly reduces the light coming from, its parent star.

The newfound system contains two planets circling a subgiant star much like the Sun except several billion years older. The inner world, Kepler-36b, is a rocky planet 1.5 times the size of Earth and weighing 4.5 times as much. It orbits about every 14 days at an average distance of less than 11 million miles.

The outer world, Kepler-36c, is a gaseous planet 3.7 times the size of Earth and weighing 8 times as much. This "hot Neptune" orbits once each 16 days at a distance of 12 million miles.

The two planets experience a conjunction every 97 days on average. At that time, they are separated by less than 5 Earth-Moon distances. Since Kepler-36c is much larger than the Moon, it presents a spectacular view in its neighbor's sky. (Coincidentally, the smaller Kepler-36b would appear about the size of the Moon when viewed from Kepler-36c.) Such close approaches stir up tremendous gravitational tides that squeeze and stretch both planets.

Researchers are struggling to understand how these two very different worlds ended up in such close orbits. Within our solar system, rocky planets reside close to the Sun while the gas giants remain distant.

Although Kepler-36 is the first planetary system found to experience such close encounters, it undoubtedly won't be the last.

"We're wondering how many more like this are out there," said Agol.

"We found this one on a first quick look," added Carter. "We're now combing through the Kepler data to try to locate more."

This result was made possible with asteroseismology. Asteroseismology is the study of stars by observing their natural oscillations. Sunlike stars resonate like musical instruments, due to sound waves trapped in their interiors. And just like a musical instrument, the larger the star, the "deeper" are its resonances. This trapped sound makes the stars gently breathe in and out, or oscillate.

Co-author Bill Chaplin (University of Birmingham, UK) noted, "Kepler-36 shows beautiful oscillations. By measuring the oscillations we were able to measure the size, mass and age of the star to exquisite precision."

He added, "Without asteroseismology, it would not have been possible to place such tight constraints on the properties of the planets."

###

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Planetrise

Public release date: 21-Jun-2012
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Contact: Christine Pulliam
cpulliam@cfa.harvard.edu
617-495-7463
Harvard-Smithsonian Center for Astrophysics